Liquid Chromatographic Determination of Naproxen and Related Compounds in Raw Materials
Open Access
- 1 November 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of AOAC INTERNATIONAL
- Vol. 73 (6) , 902-904
- https://doi.org/10.1093/jaoac/73.6.902
Abstract
A liquid chromatographic (LC) method for determination of naproxen and 8 known related compounds has been developed. The lower limit of quantitation of the related compounds In the drug Is 0.04% or less for all compounds; the precision of the drug assay method Is ca 0.4%. The method uses an octadecylsllyl column, a mobile phase of 1 % acetic acid (v/v)-methanol-acetonitrlle (48 + 22 + 30, v/v/v) and detection at 231 nm.Keywords
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