Serum Transaminase as a Measure of Myocardial Necrosis

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Abstract
In 20 normals the concentration ranged from 10 to 33 units/ml. In 24 consecutive cases of ecg proved myocardial infarction values over 40 units /ml were found in all but 2 cases, when samples were obtained within 48 hours after the onset of pain. The peak values, reached within 36 hours, ranged from 54 to 308 units/ml with a mean of 154. The return to normal was somewhat less rapid, being reached within 4-6 days. Patients with myocardial ischemia without infarction (angina pectoris) showed no elevation. Elevated levels were observed also in diffuse liver disease and following abdominal surgery. Normal levels were observed in uncomplicated cardiac failure, acute pneumothorax, pericarditis, nephrosis with marked edema, and in some cases of pulmonary infarction. Adenosine triphosphatase and serum lipoprotein lipase concentrations did not correlate with myocardial infarction.

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