Proline Benzyl Ester as Chiral Auxiliary in Barbier-Type Reactions in Aqueous Solution
- 1 January 1990
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1990 (10) , 627-628
- https://doi.org/10.1055/s-1990-21191
Abstract
α-Keto amides of proline benzyl ester [N-(α-oxoacyl)prolines] react with allyl halides in the presence of zinc in an asymmetric Barbier-type carbonyl-addition reaction to give the corresponding α-hydroxy amides in high yields and with good diastereoselectivities.Keywords
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