Distortion of allele frequency distributions provides a test for recent population bottlenecks

1 May 1998

journal article
Published by Oxford University Press (OUP) in Journal of Heredity

Vol. 89 (3) , 238-247
https://doi.org/10.1093/jhered/89.3.238

Abstract

We use population genetics theory and computer simulations to demonstrate that population bottlenecks cause a characteristic mode-shift distortion in the distribution of allele frequencies at selectively neutral loci. Bottlenecks cause alleles at low frequency ( .80) to detect an allele frequency distortion after a bottleneck of ≤20 breeding individuals when 8 to 10 polymorphic microsatellite loci are analyzed.

Keywords

LOW FREQUENCY
POLYMORPHISM
MICROSATELLITE LOCI
COMPUTER SIMULATION
ALLELE FREQUENCY
GENETIC VARIATION
POPULATION BOTTLENECK
NATURAL POPULATION
POPULATION GENETICS
POPULATION SIZE

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