The Presence of Anti-gamma Globulin Factors in Sera of Patients with Active Pulmonary Tuberculosis

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Abstract
Thirteen percent of 245 patients with chronic active pulmonary tuberculosis gave positive latex fixation tests, demonstrating the presence of anti-gamma globulin factors. These factors were shown to be present in the macroglobulin portion of the serum by analytical ultracentrifuga-tion, DEAE cellulose column chromatography, density gradient ultra-centrifugation, and treatment with mercaptoethanol. They were unrelated to the clinical status of the disease, to the globulin content, or to hepatic involvement. The factors demonstrated were identical to rheumotold factors.

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