Induction of Colon Tumors in 1,2-Dimethylhydrazine-Resistant Lobund Wistar Rats by Methylazoxymethanol Acetate2
- 1 August 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 61 (2) , 493-494
- https://doi.org/10.1093/jnci/61.2.493
Abstract
Sprague-Dawley and Lobund Wistar rats, which were sensitive and resistant to induction of colon tumors by 1,2-dimethylhydrazine (DMH), respectively, were treated with methylazoxymethanol (MAM), the product of DMH metabolism by the microsomal mixed-function oxidase system. Although the colon tissue in both stocks of rats had similar NAD+-dependent dehydrogenase activities that are considered necessary to activate MAM to an ultimate carcinogen, still a sevenfold greater incidence of colon tumors was found in the Sprague-Dawley rats, and their tumors were more extensive. The results indicated that the difference in susceptibility to colon tumor induction between the rat stocks was partially related to metabolic activation of the DMH and to other, as yet undetermined, endogenous factors.Keywords
This publication has 1 reference indexed in Scilit:
- Effects of Cholestyramine on 1,2-Dimethylhydrazine-Induced Enteric Carcinoma in Germfree RatsExperimental Biology and Medicine, 1975