The Rate of Antibody Formation in Monkeys Actively Immunized with Poliomyelitis Virus

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Abstract
In a previous report (1) it was shown that active immunity was produced by skin inoculation of virus-serum combinations, or sub-infective doses of virus-containing tissue, but that the latter gave decidedly more immunity. It is proposed, therefore, to trace the onset and subsequent rate of development of immunity following: (a) a single sub-infective dose of virus containing tissue, and (b) two inoculations, administered at different in-intervals. Although Römer and Joseph (2) claimed that only after twenty-six days were antibodies for poliomyelitis demonstrable in active immunity, Leiner and Wiesner (3) found them after seven, and in one case, two days, and Amoss (4) three and one-half days after the development of the active disease. Likewise in this laboratory (5) antibody was found in monkeys on the second day after the height of paralysis. In human beings, Netter and Levaditi (6), showed antiviral substance on the twelfth day and Flexner and Amoss (7) on the sixth day of the disease.

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