Postirradiation Protection of X-Irradiated Mice with Olive Oil

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Abstract
Olive oil administered intraperitoneally is both protective and therapeutic to whole-body X-irradiated mice. This beneficial effect is manifested during the bone marrow phase by an increase in survival, a change in mortality distribution, and a decrease in weight loss. The effect was most pronounced in the MLD group, where almost 90% of the postirradiation oil-treated animals survived. The intraperitoneal administration of lycopene had a questionable effect on irradiated mice. A carefully controlled comparative experiment on irradiation methodology demonstrates the importance of rigorously controlled physical and biological parameters in radiation protection studies.

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