Effect of glucagon on ethanol oxidation in isolated rat liver cells

1 June 1981

journal article
research article
Published by Springer Nature in Cellular and Molecular Life Sciences

Vol. 37 (6) , 545-546
https://doi.org/10.1007/bf01990039

Abstract

Addition of glucagon 5 min after ethanol was found to stimulate the rate of ethanol oxidation in hepatocytes isolated from starved rats. This stimulation is of the same order of magnitude as that mediated by asparagine. The glucagon effect is suppressed by antiproteolytic agents such as insulin or NH₄Cl. The stimulatingeffect of glucagon on ethanol oxidation is probably liked to enhanced proteolysis andan elevated glutamate level in the hepatocytes.

Keywords

GLUTAMATE

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