Adrenalin was given to dogs in their post absorptive state by stomach tube. These dogs were trained to lie quietly on the dog board during the experiment. A very marked rise of the blood sugar was observed that did not come back to normal in 21 hrs. The blood pressure was not affected. Injections of adrenalin into the jugular or vena cava gave materially greater rises in blood pressure than did equivalent injections into the portal vein or into the liver.