Influence of HLA Matching in Cadaveric Renal Transplantation: Experience from One Scandiatransplant Center

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Abstract
The outcome of 461 prospectively HLA–A, -B and -C typed and 193 prospectively HLA—DR typed cadaveric kidney transplants in one center was followed. We found a significant beneficial effect on graft survival both of HLA–A and -B as well as of HLA–DR matching between donor and recipient, while no effects of HLA–C compatibility could be detected. The effect of HLA–DR matching was clearly more pronounced than that of HLA–A and -B matching, and a possible influence of matching for HLA–A and -B could only be seen in the HLA–DR mismatched combinations. Pretransplant blood transfusions were associated with an increased graft survival only in patients receiving HLA–DR mismatched transplants. We conclude that major emphasis should be laid on obtaining HLA-DR compatibility in clinical renal transplantation.