Comparative nephrotoxicities of dibekacin, amikacin, and gentamicin in a rat model
- 1 December 1980
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 18 (6) , 983-985
- https://doi.org/10.1128/aac.18.6.983
Abstract
The nephrotoxicity of dibekacin was compared with those of gentamicin and amikacin in a rat model. The doses used were 3, 10, and 30 times the suggested human therapeutic dose on a weight basis. Indices of glomerular and tubular function failed to clearly differentiate the drugs. Dibekacin and gentamicin produced equally severe injury to the renal tissue. Slightly less damage occurred with amikacin.Keywords
This publication has 6 references indexed in Scilit:
- Comparative Nephrotoxicity of Aminoglycoside Antibiotics in RatsThe Journal of Infectious Diseases, 1978
- In Vitro Comparison of Kanamycin, Kanendomycin, Gentamicin, Amikacin, Sisomicin, and Dibekacin Against 200 Strains of Pseudomonas aeruginosaAntimicrobial Agents and Chemotherapy, 1978
- A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye BindingAnalytical Biochemistry, 1976
- Enzymuria in Gentamicin-Induced Kidney DamageAntimicrobial Agents and Chemotherapy, 1975
- 3'', 4''-DIDEOXY-KANAMYCIN B ACTIVE AGAINST KANAMYCIN-RESISTANT ESCHERICHIA COLI AND PSEUDOMONAS AERUGINOSAThe Journal of Antibiotics, 1971
- Automated and Manual Direct Methods for the Determination of Blood UreaClinical Chemistry, 1965