CONGENITAL HYPERPARATHYROIDISM AND VITAMIN D DEFICIENCY SECONDARY TO MATERNAL HYPOPARATHYROIDISM

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Abstract
A new case of congenital hyperparathyroidism secondary to maternal hypoparathyroidism is described. Neonatal roentgenograms of the skeleton showed severe bone demineralization and the distal metaphyses of the long bones were spread, frayed and cupped. Elevated levels of serum immunoreactive parathormone (iPTH) were found at the age of 41 days = 270 .mu.lEq [.mu.leq]/ml (Normal: < 50 .mu.lEq/ml). A very low plasma 25-OH-D [25-hydroxycholecalciferol] concentration (< 4 ng/ml) was found at the same time in spite of previous administration of 600 units of vitamin D every day for 18 days and in spite of healing of the bone lesions. At the age of 3 mo., 15 mg of vitamin D was given orally: iPTH levels which remainded high 3 wk before (210 .mu.lEq/ml) were normal 1 wk after this vitamin D load (37 .mu.lEq/ml). In congenital hyperparathyroidism secondary to maternal hypoparathyroidism, hyperparathyroidism increases the infants needs for vitamin D. This could result in a state of vitamin D deficiency hwich in turn would maintain the parathyroid hyperactivity. [Antibovine parathyroid hormone guinea-pig antiserum was used.].