Solute Excretion in Man during Changing Urine Flow Occurring Spontaneously and Induced by Vasopressin Injection*

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Abstract
In experiments where sudden changes in urine flow occurred spontaneously, there were no significant differences between changes in urinary endogenous creatinine and inulin concentrations, relative to those in preceding urine samples. During the developing antidiuresis after vasopressin injection in subjects maintained on a constant water load, increments in osmolality, urea and ammonium concentrations, relative to preceding diuretic values, were smaller than those in creatinine and nonurea solute concentrations. These changes are considered in relation to the generation of medullary solute concentration gradients during the developing antidiuresis.