A New Analeptic: 5,5-Diethyl-1,3-Oxazin-2,4-Dione (Dioxone): II. Antagonism to some C.N.S. Depressants

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Abstract
Dioxone (5,5-diethyl-1,3-oxazine-2,4-dione), has been found to exhibit a strong antagonistic effect to barbiturates and chlorpromazine. Given subcutaneously, dioxone significantly reduces the mortality in mice from phenobarbitone and allows an increase in the LD50 of quinalbarbitone and hexobarbitone in mice, and pentobarbitone in rats and mice, thus showing its barbiturate antagonist action both at lethal and depressant dose levels. As with leptazol and bemegride, dioxone does not show any significant effect on the depressant activity of ethanol. It has no effect on lethal doses of chlorpromazine but it has an awakening effect on mice sedated with the drug. The pharmacological actions of dioxone, suggest that its mode of action is functional, rather than at a cellular competition level.