Prolactin Responsiveness to Repeated Decremental Doses of Sulpiride

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Abstract
The variation in the prolactin [PRL] response to sulpiride was studied in 6 normal men by repeating the same dose of the drug (50 mg) after 24 h and on 3 subsequent occasions, repeating this 2 day test at an interval of 6 days with progressively halved doses of sulpiride. A similar PRL response occurred on the 1st day of each test period and the peak response was highly significant (P < 0.001), occurring within 30 min. A gross blunting of the PRL response occurred on the 1st day of each test period and the peak response was highly significant (P < 0.001), occurring within 30 min. A gross blunting of the PRL response on the 2nd day of each period was noted throughout the study. The difference in .DELTA. PRL between the 1st and 2nd day of each period was highly significant (P < 0.001). The .DELTA. PRL increment on the 2nd day was inversely proportional to the dose of sulpiride; the differences in .DELTA. PRL between periods 1 and 3 and periods 1 and 4 being highly significant (P < 0.001). A much lower dose of sulpiride than that normally used is adequate to stimulate PRL secretion, and care must be taken in the timing of repeat testing.

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