Clonal 6p21 rearrangement is restricted to the mesenchymal component of an endometrial polyp
- 1 October 1992
- journal article
- research article
- Published by Wiley in Genes, Chromosomes and Cancer
- Vol. 5 (3) , 260-263
- https://doi.org/10.1002/gcc.2870050315
Abstract
Previous cytogenetic analyses revealed t(6;20)(p21;q 13) in two endometrial polyps. We karyotyped a large endometrial polyp in which 19 of 25 metaphase cells contained a t(1;6;4)(q21;p21;q 13). Subsequent combined immunohistochernical/cytogenetic analysis showed all aberrant metaphase cells to be of mesenchymal derivation, whereas epithelial cells from the polyp were diploid. These studies indicate that rearrangement of chromosome band 6p21 is a characteristic cytogenetic aberration in the stromal component of endometrial polyps.Keywords
This publication has 11 references indexed in Scilit:
- Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factorPublished by Elsevier ,1991
- Is t(6;20)(p21;q13) a characteristic chromosome change in endometrial polyps?Genes, Chromosomes and Cancer, 1991
- Responsiveness of Human Endometrial Stromal Cells to CytokinesaAnnals of the New York Academy of Sciences, 1991
- Involvement of 6p in an endometrial polypCancer Genetics and Cytogenetics, 1991
- Fibroblast-mediated acceleration of human epithelial tumor growth in vivo.Proceedings of the National Academy of Sciences, 1990
- The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias.Proceedings of the National Academy of Sciences, 1989
- Biphasic tumours: Clues to possible histogenesis in developmental processThe Journal of Pathology, 1989
- Human KGF is FGF-Related with Properties of a Paracrine Effector of Epithelial Cell GrowthScience, 1989
- Benign Diseases of the EndometriumPublished by Springer Nature ,1987
- Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in VitroScience, 1985