Benzophenanthridine Alkaloids Isolated fromEschscholtzia californicaCell Suspension Cultures Interact with Vasopressin (V1) Receptors
- 1 February 1992
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 58 (01) , 35-38
- https://doi.org/10.1055/s-2006-961385
Abstract
Chelerythrine and sanguinarine, two benzophenanthridine alkaloids, have been isolated from a crude methanolic extract of Eschscholtzia californica cell suspension cultures by successive fractionations. These two molecules exhibited affinity for rat liver vasopressin V1 receptors and are competitive inhibitors of [3 H]-vasopressin binding within the micromolar range (Ki). Chelerythrine and sanguinarine represent two of the first non-peptidic structures providing original chemical leads for the design of synthetic vasopressin compounds.Keywords
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