Metal complexes of bilirubin in aprotic solvents

Abstract
Bilirubin reacts with zinc acetate, cadmium acetate or cobaltous acetate in dry dipolar aprotic solvents to form highly coloured complexes. The complex formed in NN-dimethylformamide can be isolated as a solid with bilirubin:zinc:acetate:NN-dimethylformamide molar proportions of 1:3:2:2. Water will decompose these complexes, with the regeneration of bilirubin.

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