CALCIUM DEPLETION OF SYNAPTOSOMES AFTER MORPHINE TREATMENT
Open Access
- 1 August 1976
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 57 (4) , 521-526
- https://doi.org/10.1111/j.1476-5381.1976.tb10379.x
Abstract
1 It was confirmed that morphine administration in vivo produced a selective decrease in the calcium content of synaptosomal fractions prepared from rat cerebral cortices. This effect was prevented by naloxone. 2 After morphine or naloxone, there were no changes in the sodium, potassium and magnesium contents of any of the seven subcellular fractions tested. 3 Since the selective calcium loss was found to occur from fractions similar to those reported to exhibit opiate receptor binding, it is concluded that calcium may play a role in the action of narcotic agonist drugs.Keywords
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