Bioevaluation of the antibacterial flumequine for enteric use

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Abstract
The antibacterial activity of flumequine was further characterized by in vitro and in vivo procedures. Assay of the minimal inhibitory concentrations for selected enteric pathogens suggests that clinical isolates may be sensitive to approximately 1 μg/ml of drug. The equivalence of flumequine and ampicillin administered by the oral route (100 mg/kg/day) was demonstrated in a mouse typhoid infection model (Salmonella typhimurium).

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