THE INFLUENCE OF ANAESTHESIA AND SURGERY ON PLASMA CORTISOL, INSULIN AND FREE FATTY ACIDS

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Abstract
The plasma cortisol level of patients anaesthetized for 1 hour with thiopentone and nitrous oxide was found to remain unchanged. During body surface surgery it rose slightly, and during intra-abdominal surgery it rose to more than double the resting value. The blood sugar under the same circumstances changed in a qualitatively similar manner and the free fatty acids appeared to fall during anaesthesia without surgery, changed little during body surface surgery, and rose during intra-abdominal surgery. Plasma insulin during both types of surgery showed no significant change.

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