Interspecies Comparison of Brain Ganglioside Patterns Studied by Two‐Dimensional Thin‐Layer Chromatography

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Abstract
Brain gangliosides from 4 vertebrate classes (Pisces [goldfish], Amphibia [Rana berlanderi], Aves [White Leghorn chicken] and Mammalia [CD-1 mouse, Long-Evans hooded rat, Syrian golden hamster, macaque monkey and cow]) were studied by patterns generated with the use 2-dimensional TLC. To retain possible alkali-labile gangliosides, samples were not base-hydrolyzed. Resultant chromatograms revealed complex patterns of the major known gangliosides and a number of minor and trace molecular species previously unresolved. More than 30 resorcinol-positive components were detected in mammalian neural samples. Both qualitative and quantitative differences in the chromatogram patterns between the vertebrate classes were indicated. Potentially greater qualitative similarity exists between the lower and higher classes than has previously been noted.

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