Effects of Roentgen Radiation and Cortisone on Susceptibility of Mice to Candida Albicans

Open Access
Publisher Website
Google Scholar
Abstract
Summary: Pretreatment of adult Swiss albino mice with cortisone and roentgen radiation, either singly or in combination, reduced inherent resistance to experimental infection with Candida albicans. In the dosage range tested, x-radiation enhanced susceptibility more effectively than did cortisone. Since the depressive action upon host resistance of cortisone and radiation in combination exceeds that exerted by any dose of either agent singly, or the additive effects of both agents, the combined action was interpreted as synergistic in nature. Mice pretreated provide animals for diagnostic and experimental studies of moniliasis.