Symposium on Exoerythrocytic Forms of Malarial Parasites. V. Studies in Tissue Culture of Exoerythrocytic Schizogony in Avian Malarial Parasites

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Abstract
This is a review of the methods for and results from the cultivation of exoerythrocytic stages of avian malaria. Although the most successful studies have been conducted with Plasmodium gallinaceum, success has been attained in culturing in vitro the exoerythrocytic stages of P. elongatum, P. cathemerium, P. lophurae, and P. relictum. In tissue cultures the exoerythrocytic stages were found in macro-phages and epithelioid cells. Morphologically they resembled, in general, the exoerythrocytic stages seen in capillary endothelium of infected chickens but unlike the latter they exhibited a very prominent granule near the nucleus. Exoerythrocytic stages in culture resemble in size and merozoite number more nearly the cryptozoites than the phanerozoites of infected birds. There have been many negative attempts to establish tissue cultures from sporozoites. Little progress has been made in the use of tissue cultures for the acquisition of new information about exoerythrocytic stages.

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