Reaction following treatment of murine borreliosis and Shwartzman type reaction with borrelial sonicates

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Abstract
Treatment of experimental murine borreliosis induced an acute transient fall in temperature, leukopenia and thrombocytopenia with appearance of circulating endotoxin-like material. This reaction to treatment could be reproduced by the inoculation of borrelial sonicates into infected mice or by 2 injections of the same sonicate given 24 h apart into normal mice. Sensitization or precipitation of the reaction could not be induced by Escherichia coli lipopolysaccharide, although a reaction indistinguishable from the reaction to treatment could be provoked in mice by 2 successive injections of lipopolysaccharide given 24 h apart. The nature of this reaction in mice was investigated and the relation of both reactions to the Shwartzman reaction and endotoxin is shown.