ELECTRON MICROSCOPIC OBSERVATIONS ON THE EMIGRATION OF LEUCOCYTES

Publisher Website
Google Scholar
Abstract
SUMMARY: Electron micrographs have been made of the capillaries and small venules in rat skin at a time following the intradermal injection of homologous serum at which active leucocytic emigration occurs. Stages in the migration of blood leucocytes are illustrated.Polymorphs escape from small vessels by insertion of a pseudopod into the endothelium followed by amoeboid‐like migration of the cell through the wall of the blood vessel. In some cases penetration occurs down intercellular junctions but in most instances passage through endothelium at other points cannot be excluded. Appreciable delay commonly occurs at either the basement membrane or peri‐endothelial cell layer before eventual escape of the cell into surrounding tissues. Monocytes apparently escape by a similar process.After passage of leucocytes through the endothelium no residual evidence of such passage is visible. Neither endothelial cells nor the intercellular substance between them differ from their normal structure in vessels in which leucocytic emigration is occurring.
Funding Information
  • Anti-Cancer Council of Victoria

This publication has 4 references indexed in Scilit: