A Comparative Trial of Oral Chloroquine and Oral Co-Trimoxazole in Vivax Malaria in Children

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Abstract
Responses of parasitemia and fever in vivax malaria to standard doses of chloroquine and different dosage schedules of co-trimoxazole were compared in 165 children. Though both the drugs were effective, chloroquine was significantly faster in clearing parasitemia than all the dosage schedules of co-trimoxazole. No statistically significant difference was observed in rapidity of defervescence between chloroquine and the two high daily dosage regimens of co-trimoxazole. Gastrointestinal intolerance was persistantly higher with chloroquine. Asymptomatic sulphonamide crystalluria was seen in a large number of cases receiving the two high daily dosage schedules of co-trimoxazole.

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