Cerebrospinal Fluid Neuropeptide Y in Alzheimer’s Disease

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Abstract
The cerebrospinal fluid neuropeptide Y level was measured by radioimmunoassay in 20 patients with probable Alzheimer’s disease and in 19 controls. The mean level was lower in patients (69.5 ± 36.7 pg/ml) than in controls (103 ± 21.8 pg/ml; p < 0.001). Patients with a disease duration of >2 years had cerebrospinal fluid neuropeptide Y levels lower than those with shorter disease duration (p < 0.02). These results suggest that neuropeptide Y containing cells may be involved in Alzheimer’s disease. No correlation was found between neuropeptide Y levels and degree of cognitive impairment or age at disease onset.