Influence of the Uterus Upon Cyclic Ovarian Activity in the Guinea Pig

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Abstract
Mature guinea pigs subjected to partial hysterectomy were characterized by prolonged diestrous intervals which eventually returned to normal by the 5th or 6th postoperative cycle. The vaginal cycles returned to normal duration more rapidly with increasing amounts of uterine tissue left intact. It was also observed that normal cyclic ovarian activity could be attained in females subjected to the removal of both uterine horns at 3 weeks of age. The data suggested, however, that some uterine tissue must be present for normal luteolytic activity, for a complete hysterectomy resulted in a prolonged maintenance of luteal activity up to 7 months post-hysterectomy. It would appear that specific portions of the uterus are not involved in such utero-ovarian interrelationships.