Occurrence of circulating 7-deoxyaglycone metabolites of 4?-deoxydoxorubicin in man
- 1 January 1987
- journal article
- research article
- Published by Springer Nature in Cancer Chemotherapy and Pharmacology
- Vol. 20 (3) , 263-264
- https://doi.org/10.1007/bf00570499
Abstract
In five cancer patients we have determined the pharmacokinetics of 4′-deoxydoxorubicin (4′-DOX), its alcoholic metabolite 4′-deoxydoxorubicinol and the occurrence of circulating 7-deoxyaglycone metabolites. The 7-deoxyaglycone of the alcohol metabolite, the major aglycone of Adriamycin (ADR) present in man, was not detected in any serum sample. The 7-deoxyaglycone of the parent drug, which appears in concentrations in excess of 30ng/ml after ADR administration, was detected in only 2/5 patients in trace amounts. These preliminary data indicate a difference in biotransformation between ADR and 4′-DOX despite their close structural similarities.Keywords
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