(S)‐2‐Chloropropanoyl chloride. A convenient reagent for the determination of the enantiomeric composition of α‐substituted α‐hydroxy acids
- 1 January 1990
- journal article
- research article
- Published by Wiley in Recueil des Travaux Chimiques des Pays-Bas
- Vol. 109 (9) , 479-480
- https://doi.org/10.1002/recl.19901090906
Abstract
(S)‐2‐Chloropropanoyl chloride reacts cleanly with α‐substituted α‐hydroxy acids (or esters) to give O‐acyl derivatives, which can be used for the establishment of optical purities of the acids or their esters.Keywords
This publication has 12 references indexed in Scilit:
- Use of carboxylic acids as chiral solvating agents for the determination of optical purity of chiral amines by NMR spectroscopyThe Journal of Organic Chemistry, 1988
- .alpha.-Methoxy-.alpha.-(trifluoromethyl)benzyl isocyanate. A convenient reagent for the determination of the enantiomeric composition of primary and secondary aminesThe Journal of Organic Chemistry, 1988
- Synthesis of optically pure .alpha.-alkylated .alpha.-amino acids and a single-step method for enantiomeric excess determinationThe Journal of Organic Chemistry, 1988
- The Determination of Small Amounts of Enantiomeric Impurities in α-Halo Carboxylic AcidsSynthesis, 1987
- Enantiomeric excess determination without chiral auxiliary compounds. A new phosphorus-31 NMR method for amino acid esters and primary aminesThe Journal of Organic Chemistry, 1986
- Simple phosphorus-31 NMR method for the determination of enantiomeric purity of alcohols not requiring any chiral auxiliary compoundsJournal of the American Chemical Society, 1985
- Determination of enantiomeric purities of alcohols and amines by a phosphorus-31 NMR techniqueJournal of the American Chemical Society, 1984
- NMR Chiral Solvating AgentsTopics in Stereochemistry, 1982
- Influence of Optically Active Acyl Groups on the Enzymatic Hydrolysis of N-Acylated-L-amino AcidsJournal of the American Chemical Society, 1954
- Die Konfiguration der α‐Brom‐propionsäure (8. Mitteilung über sterische Reihen)Berichte der deutschen chemischen Gesellschaft (A and B Series), 1927