Fecal Microbiota Composition and Frailty

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Abstract
The relationship between fecal microbiota composition and frailty in the elderly was studied. Fecal samples from volunteers with high frailty scores showed a significant reduction in the number of lactobacilli (26-fold). At much higher population levels, both theBacteroides/Prevotella(threefold) and theFaecalibacterium prausnitzii(fourfold) groups showed a significant reduction in percentage of total number of hybridizable bacteria in the elderly with high frailty scores. In contrast to this, the number ofEnterobacteriaceaewas significantly higher (sevenfold) in samples from very frail volunteers.