Polymorphic Mutation Frequencies in Escherichia coli : Emergence of Weak Mutators in Clinical Isolates
Open Access
- 15 August 2004
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 186 (16) , 5538-5542
- https://doi.org/10.1128/jb.186.16.5538-5542.2004
Abstract
Polymorphisms in the rifampin resistance mutation frequency (f) were studied in 696 Escherichia coli strains from Spain, Sweden, and Denmark. Of the 696 strains, 23% were weakly hypermutable (4 × 10−8 ≤ f < 4 × 10−7), and 0.7% were strongly hypermutable (f ≥ 4 × 10−7). Weak mutators were apparently more frequent in southern Europe and in blood isolates (38%) than in urinary tract isolates (25%) and feces of healthy volunteers (11%).Keywords
This publication has 23 references indexed in Scilit:
- Escherichia coli Mutators Present an Enhanced Risk for Emergence of Antibiotic Resistance during Urinary Tract InfectionsAntimicrobial Agents and Chemotherapy, 2004
- Mutation Rate and Evolution of Fluoroquinolone Resistance in Escherichia coli Isolates from Patients with Urinary Tract InfectionsAntimicrobial Agents and Chemotherapy, 2003
- Interactions among Strategies Associated with Bacterial Infection: Pathogenicity, Epidemicity, and Antibiotic ResistanceClinical Microbiology Reviews, 2002
- High Frequency of Mutator Strains among Human Uropathogenic Escherichia coli IsolatesJournal of Bacteriology, 2002
- Variation in antibiotic use in the European UnionThe Lancet, 2001
- Costs and Benefits of High Mutation Rates: Adaptive Evolution of Bacteria in the Mouse GutScience, 2001
- High Frequency of Hypermutable Pseudomonas aeruginosa in Cystic Fibrosis Lung InfectionScience, 2000
- Highly Variable Mutation Rates in Commensal and Pathogenic Escherichia coliScience, 1997
- High Mutation Frequencies Among Escherichia coli and Salmonella PathogensScience, 1996
- Competition Between High and Low Mutating Strains of Escherichia coliEvolution, 1983