Solution conformation of septamycin and its sodium salt.
- 1 January 1978
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 31 (4) , 294-301
- https://doi.org/10.7164/antibiotics.31.294
Abstract
The interpretation of the 300 MHz 1H-NMR spectra of septamycin (1) and its Na salt (1+) permits extraction of most of the parameters revealing their resemblant conformations in solution. The backbone forms a pseudocyclic structure closed by head-to-tail H bonding between the carboxylate fragment and the OH-14. In 1+, the Na+ is trapped in a central hole by coordinating around it 6-7 O atoms (including COO-). The external lipophilic zone of the molecule keeps the Na+ away from the surroundings. The dangling sugar-like fragment does not participate in the metal binding. It was not possible to detect any H2O molecule participating in the cyclization of septamycin-free acid, nor in septamycin-Na+, as was found in an X-ray study for the p-bromophenacyl ester.This publication has 2 references indexed in Scilit:
- Solution conformation of the ionophore A23187 and its magnesium saltBioorganic Chemistry, 1977
- Solution conformation of lasalocid and lasalocid-Na+ (X-537A)Bioorganic Chemistry, 1976