Immunologic Reconstitution in Severe Combined Immunodeficiency without Bone-Marrow Chromosomal Chimerism

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Abstract
An 11-month-old male infant with severe combined immunodeficiency was immunologically reconstituted by bone-marrow transplantation from a female sibling whose cells were HL-A compatible on mixed leukocyte culture. The patient's lymphocytes demonstrated multiple extraneous HL-A antigens (up to 10 at one time), some of which were not present in the parents or the four siblings; this typing anomaly delayed bone-marrow donor selection. These additional antigens were nonstimulatory in mixed leukocyte culture, and since they were found in two similar patients, may represent an anomaly peculiar to combined immunodeficiency.