THE EFFECT OF HYPOTHALAMIC LESIONS ON THYROID FUNCTION IN THE DOG12

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Abstract
Thyroidal uptake of radioactive I and thyroid weight and histology were analyzed in 23 dogs with hypothalamic lesions and correlated with the eosinopenic response to stress, adrenal weight and histology, and gonadal weight. and histology. Five dogs showed definite depression of thyroidal I131 uptake, and histologic evidence of thyroidal atrophy. In these animals, lesions were localized to the region in and just above the anterior end of the median eminence. Thyroid function and histology were normal in animals with lesions elsewhere, including the posterior and middle portion of the median eminence. There was no consistent correlation between thyroid depression and depressions of other pituitary controlled endocrines in the dogs with hypothalamic lesions. Rather, the type of endocrine picture produced correlated roughly with the site of the hypothalamic destruction.