The Diagnostic Implication of Restriction of Salt Intake and Adminitstration of Various Drugs in Primary Aldosteronism

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Abstract
The effect of restriction of salt intake and administration of various drugs upon the aldosterone secretion was studied in patients with primary aldosteronism and those with hypertension of other causes by determining the urinary output of aldosterone. Six patients with proved primary aldosteronism had increased urinary aldosterone excretion which responded to the administration of spironolactone (SC -9420) K+ or dihydroxycorticosterone acetate (DOCA.) Electrolytes in serum and urine inducedno change by the administration of DOCA in this disease. The rise in serum K+ levels was observed during administration of SC -9420 or salt restriction. These observations may prove useful steps in the differential diagnosis of primary aldosteronism, which is worthy of consideration in the patients with hypertension and suspected aldosteronism.