Lack of association between atopy and RsaI polymorphism within intron 2 of the Pc?RI-? gene in a Spanish population sample
- 1 November 1998
- Vol. 53 (11) , 1083-1086
- https://doi.org/10.1111/j.1398-9995.1998.tb03819.x
Abstract
The B genotype of RasI polymorphism located within intron 2 of the Fc-IgE receptor I (Fc(epsilon)RI) gene was previously found to be increased in atopic patients from a Japanese population sample. We studied these A/B genotypes in 70 Spanish atopic patients, and the results were compared to those of 51 nonatopic controls. RasI polymorphisms were studied by specific digestion of polymerase chain reaction fragments followed by polyacrylamide gel electrophoresis. The polymorphism frequency (A/A: 25/70, A/B: 28/70, B/B: 17/70) found in patients did not differ from the frequency in nonatopic control subjects. We did not find RasI polymorphisms associated with atopic disease. The genetic findings in atopy and asthma may be very different according to ethnic and local characteristics, and they must be carefully verified in different population samples.Keywords
This publication has 9 references indexed in Scilit:
- Association between Fc ɛ RIβ and atopic disorder in Japanese population?The Lancet, 1996
- Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population [published erratum appears in Hum Mol Genet 1996 Dec;5(12):2068]Human Molecular Genetics, 1996
- A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsivenessHuman Molecular Genetics, 1996
- Association between Fc∈ RIβ and atopic disorder in a Japanese populationThe Lancet, 1996
- Linkage of high-affinity IgE receptor gene with bronchial hyperreactivity, even in absence of atopyThe Lancet, 1995
- Who's to blame for asthma?The Lancet, 1995
- Association between atopy and variants of the β subunit of the high–affinity immunoglobulin E receptorNature Genetics, 1994
- A rapid procedure for extracting genomic DNA from leukocytesNucleic Acids Research, 1991
- LINKAGE BETWEEN IMMUNOGLOBULIN E RESPONSES UNDERLYING ASTHMA AND RHINITIS AND CHROMOSOME 11qThe Lancet, 1989