Contractile responses of canine coronary collateral vessels.

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Abstract
The responses of coronary collateral vessels to various vasoconstrictors were examined and compared with responses of 3 different divisions of the native coronary arterial trees in dogs. Only high concentrations of phenylephrine induced contractions in collateral vessels and medium coronary arteries, whereas even a high concentration of this agent did not affect small coronary arteries. Lower concentrations of serotonin or ergonovine elicited contractions in collateral vessels, and medium and large coronary arteries, but even a high concentration of these agents did not affect small coronary arteries. Angiotensin II (10-7 M) elicited prominent contractions in the following order: small vessels, collateral vessels, medium and large coronary arteries. Well-developed collateral vessels evidently behave like native medium diameter coronary artery. The tonus of collateral vessels is apparently influenced by various vasoactive substances. [The reaction of collateral vessels to ischemia in cardiac muscle is discussed.].

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