Interleukin‐1 Modulation of Human Placental Trophoblast Proliferation

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Abstract
During early pregnancy, interleukin‐1 (IL‐1) is mainly produced and secreted by maternal decidua. Yet, its biological function on placental cells is not well defined. In this study, we employed JAR choriocarcinoma cell line as a model of human placental trophoblast to study the effect of IL‐1. Treatment with recombinant human IL‐1β resulted in significant inhibition of JAR proliferation (P < .05) paralleled with increased cytotoxicity. The inhibitory effect was blocked by both IL‐1 receptor antagonist (IL‐1Ra) and antihuman IL‐1β monoclonal antibody. Analyzing the mode of action, IL‐1β was found to induce cell cycle arrest in the G0/G1 phase and triggered apoptotic cell death. These findings demonstrated that IL‐1 regulates human trophoblast growth by induction of cell cycle delay and cell death.
Funding Information
  • BIOTEC (BT-B-06-MM-18-4504)