Abstract
Subcutaneous administration every second day of one unit of long acting ACTH to female albino rats before and during mating significantly depresses the sex ratio at birth of their first litters. The controls were litter-mates, kept in the same cage, mated with the same male and injected with Saline. Of 407 control births 227 were male and 180 female; of 369 births in the experimental group 170 were male and 199 female.

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