Acyl‐CoA dehydrogenases and acyl‐CoA oxidases
Open Access
- 15 January 2004
- journal article
- review article
- Published by Wiley in European Journal of Biochemistry
- Vol. 271 (3) , 483-493
- https://doi.org/10.1046/j.1432-1033.2003.03948.x
Abstract
Acyl‐CoA dehydrogenases and acyl‐CoA oxidases are two closely related FAD‐containing enzyme families that are present in mitochondria and peroxisomes, respectively. They catalyze the dehydrogenation of acyl‐CoA thioesters to the corresponding trans‐2‐enoyl‐CoA. This review examines the structure of medium chain acyl‐CoA dehydrogenase, as a representative of the dehydrogenase family, with respect to the catalytic mechanism and its broad chain length specificity. Comparing the structures of four other acyl‐CoA dehydrogenases provides further insights into the structural basis for the substrate specificity of each of these enzymes. In addition, the structure of peroxisomal acyl‐CoA oxidase II from rat liver is compared to that of medium chain acyl‐CoA dehydrogenase, and the structural basis for their different oxidative half reactions is discussed.Keywords
This publication has 35 references indexed in Scilit:
- Protein Dynamics Enhance Electronic Coupling in Electron Transfer ComplexesJournal of Biological Chemistry, 2001
- The Function of Arg-94 in the Oxidation and Decarboxylation of Glutaryl-CoA by Human Glutaryl-CoA DehydrogenasePublished by Elsevier ,2001
- The medium-/long-chain fatty acyl-CoA dehydrogenase (fadF) gene of Salmonella typhimurium is a phase 1 starvation-stress response (SSR) locusMicrobiology, 1999
- Molecular Cloning and Expression of cDNA Encoding 3α,7α,12α-Trihydroxy-5β-cholestanoyl-CoA Oxidase from Rabbit LiverPublished by Elsevier ,1997
- Functional Expression of 2 Forms of Rat Acyl-CoA Oxidase and Their Substrate SpecificitiesBiochemical and Biophysical Research Communications, 1995
- Cloning of glutaryl-CoA dehydrogenase cDNA, and expression of wild type and mutant enzymes in Escherichia coliHuman Molecular Genetics, 1995
- Identification of the Active Site Catalytic Residue in Human Isovaleryl-CoA DehydrogenaseBiochemistry, 1995
- Three-Dimensional Structure of Butyryl-CoA Dehydrogenase from Megasphaera elsdeniiBiochemistry, 1995
- MOLSCRIPT: a program to produce both detailed and schematic plots of protein structuresJournal of Applied Crystallography, 1991
- Reactivity of medium-chain acyl-CoA dehydrogenase toward molecular oxygenBiochemistry, 1991