Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase
Open Access
- 7 August 1995
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 369 (2-3) , 136-139
- https://doi.org/10.1016/0014-5793(95)00763-y
Abstract
Nitric oxide (NO) reversibly inhibits mitochondrial respiration by competing with oxygen at cytochrome oxidase. Concentrations of NO measured in a range of biological systems are similar to those shown to inhibit cytochrome oxidase and mitochondrial respiration. Inhibition of NO synthesis results in a stimulation of respiration in a number of systems. It is proposed that NO exerts some of its main physiological and pathological effects on cell functions by inhibiting cytochrome oxidase. Further NO may be a physiological regulator of the affinity of mitochondrial respiration for oxygen, enabling mitochondria to act as sensors of oxygen over the physiological range.Keywords
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