Minimal change nephrotic syndrome associated with rifampicin treatment

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Abstract
Rifampicin is a commonly used anti‐tuberculosis agent which has been reported to have some adverse effects, including nephrotoxicity [1–9]. The most frequent form of nephrotoxicity is a syndrome consisting of acute renal failure, with tubular necrosis as pathological finding, with or without haemolysis and thrombocytopenia, generally occurring during intermittent or interrupted treatment. Other forms of nephrotoxicity are interstitial nephritis with or without mild glomerular lesions, rapidly progressive glomerulonephritis and light chain proteinuria [3]. We herein report a case of minimal change nephrotic syndrome (MCNS) after rifampicin treatment which was not associated with acute interstitial nephritis or any other glomerular lesion, followed by complete remission after discontinuation of rifampicin.