Toxicity of Chronic Low Level Exposures to Toluene Diisocyanate in Animals

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Abstract
The toxicity of repeated inhalation exposures to 0.1 ppm of toluene diisocyanate was studied in rats, rabbits and guinea pigs. The experiment consisted of two parts: (A) 38 six-hour weekly exposures on rabbits and rats, (B) 58 six-hour daily exposures on rabbits, rats and guinea pigs. The development of bronchiolitis fibrosa obliterans in rats is the complication of primary interest. A description and illustrations of the lesion are given. Other biological effects of toluene diisocyanate are discussed.