Serum concentrations of clozapine determined by nitrogen selective gas chromatography
- 1 January 1977
- journal article
- conference paper
- Published by Springer Nature in Archives of Toxicology
- Vol. 37 (4) , 313-318
- https://doi.org/10.1007/bf00330823
Abstract
A simple gas-liquid-chromatographic method employing a nitrogen selective detector for the quantitative determination of clozapine in serum is presented. The method involves after the addition of dibenzepine as internal standard the extraction into diethylether followed by analysis of the extract dissolved in methanol. Detector linearity was established over the range of 100–1000 ng/ml serum. Clozapine levels of 9 manic patients analysed by this method are presented and discussed. A linear relationship between daily intake (mg/kg body weight) and serum levels (ng/ml) was established. Es wird eine einfache gaschromatographische Methode zur Bestimmung von Clozapin-Serumkonzentrationen unter Benutzung eines stickstoffspezifischen Detektors vorgestellt. Nach Zusatz von Dibenzepin als innerem Standard erfolgt zunächst die Extraktion mit Äther, danach die Analyse des in Methanol gelösten Extrakts. Die Detektorlinearität konnte über einen Konzentrationsbereich von 100–1000 ng/ml Serum gesichert werden. Die mit dieser Methode gemessenen Clozapinspiegel von 9 manischen Patienten werden diskutiert. Es wurde eine lineare Beziehung zwischen Dosis (mg/kg Körpergewicht) und Serumspiegel (ng/ml) festgestellt.This publication has 6 references indexed in Scilit:
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