Apolipoprotein E and cholesterol metabolism
- 1 March 1983
- journal article
- heinrich wieland-preis-vorlesung
- Published by Springer Nature in Journal of Molecular Medicine
- Vol. 61 (5) , 225-232
- https://doi.org/10.1007/bf01496128
Abstract
The role of apo-E in mediating lipoprotein interaction with specific receptors has been established. Through the use of selective chemical modification of specific amino acid residues of certain lipoproteins, we have gained insight into the importance of the lysine and arginine residues in this process. This understanding has been expanded by structure-function studies of mutant forms of apo-E. These studies have revealed important information concerning the genetic heterogeneity of the apo-E isoforms, focusing attention on the importance of a specific region of apo-E in the binding process.Keywords
This publication has 28 references indexed in Scilit:
- Hepatic Catabolism of Low Density Lipoprotein: Mechanisms and Metabolic ConsequencesHepatology, 1982
- Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man. Apo-B,E and apo-E receptors.Journal of Clinical Investigation, 1981
- Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows.Journal of Clinical Investigation, 1981
- Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modificationBiochemistry, 1981
- LIPOPROTEIN BIOSYNTHESIS AND METABOLISMAnnals of the New York Academy of Sciences, 1980
- ALTERATIONS IN METABOLIC ACTIVITY OF PLASMA LIPOPROTEINS FOLLOWING SELECTIVE CHEMICAL MODIFICATION OF THE APOPROTEINSAnnals of the New York Academy of Sciences, 1980
- Altered Metabolism (In Vivo and In Vitro) of Plasma Lipoproteins after Selective Chemical Modification of Lysine Residues of the ApoproteinsJournal of Clinical Investigation, 1979
- Familial hyperlipoproteinemia type III: Deficiency of a specific apolipoprotein (APO E‐III) in the very‐low‐density lipoproteinsFEBS Letters, 1975
- The removal of cholesterol from aortic smooth muscle cells in culture and landschutz ascites cells by fractions of human high-density apolipoproteinBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1975
- Regulation of cellular sterol flux and synthesis by human serum lipoproteinsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1974