Interleukin-6 Directly Inhibits Osteoclast Differentiation by Suppressing Receptor Activator of NF-κB Signaling Pathways
Open Access
- 1 April 2008
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 283 (17) , 11535-11540
- https://doi.org/10.1074/jbc.m607999200
Abstract
No abstract availableKeywords
This publication has 29 references indexed in Scilit:
- A critical role for interleukin-6 family-mediated Stat3 activation in osteoblast differentiation and bone formationBone, 2006
- Osteoporosis with increased osteoclastogenesis in hematopoietic cell-specific STAT3-deficient miceBiochemical and Biophysical Research Communications, 2005
- Osteoclast differentiation and activationNature, 2003
- Control of osteoblast function and regulation of bone massNature, 2003
- Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptorsOncogene, 2000
- STAT3 Activation in Stromal/Osteoblastic Cells Is Required for Induction of the Receptor Activator of NF-κB Ligand and Stimulation of Osteoclastogenesis by gp130-utilizing Cytokines or Interleukin-1 but Not 1,25-Dihydroxyvitamin D3 or Parathyroid HormoneJournal of Biological Chemistry, 1999
- Combination of Interleukin-6 and Soluble Interleukin-6 Receptors Induces Differentiation and Activation of JAK-STAT and MAP Kinase Pathways in MG-63 Human Osteoblastic CellsJournal of Bone and Mineral Research, 1998
- Osteoclasts Are Present in gp130-Deficient MiceEndocrinology, 1997
- Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors.The Journal of Experimental Medicine, 1995
- Role of cytokines in bone resorptionBone, 1995