Effect of Methylphenidate on Cardiovascular Actions of Pressor Amines

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Abstract
Methylphenidate, 15 mg/kg intravenously, alters the pressor responses in the anesthetized dog to a series of phenylalkylamines. The amines affected by this central nervous system stimulant are influenced in such a way as to fall into 3 structurally distinct categories which are augmented or not significantly affected; reversibly blocked; or irreversibly blocked.